The study of chemical constituents of Hippeastrum vittatum
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DOI: 10.25236/iczbe.2018.003
Author(s)
Xin Guosong, He Jiaxin, Yu Wenjing, Ji Yubin
Corresponding Author
Ji Yubin
Abstract
Objective aiming to study the chemical composition of hippeastrum dry leaves. Methods The separation techniques of silica gel column chromatography, ODS column chromatography, HPLC analysis and preparation of liquid phase were adopted, and the methods of MS, NMR and other methods of spectroscopy were used to identify the structure of the compound. Results Four monomer compounds were obtained by separation and purification, according to the physicochemical properties of the obtained compounds, and the structure of the compounds was identified by the spectra of 1H-NMR, 13C-NMR and MS, namely(2S)-7,3'-dihydroxy-4'-methoxy-flavan and (2S)-7-hydroxy-3'',4'-dimethoxy-flavan. In the dichloromethane partial extract, compound 3 was prepared as 4'-dihydroxy-7,3'-methoxy-flavan and the No.4 compound 7,4'-dihydroxy-3'-methoxy-flavan finally. Conclusion This four compounds is isolated from Hippeastrum. Compound 1 and compound 4 have strong anti-tumor activity, compound 2 and compound 3 antitumor activity.
Keywords
Hippeastrum, Lycoris, Chemical Composition, Structure Identification