Author(s)

Changlei Li, Huiling Yi, Xiaoqing Chen, Baomiao Ma

Corresponding Author

Baomiao Ma

Abstract

To study the application and effect of IVC independent air supply system in the breeding of SCID-Beige mice. Since April 2018, a 15m2 room was randomly selected from SPF Animal Laboratory of the Laboratory Animal Center, and an IVC independent air supply system was installed on the basis of the barrier system as the experimental group; another room with the same area and only the barrier system was randomly selected as the control group. After the beginning of the experiment, 12 female rats and 12 male rats were placed in the experimental group and the control group respectively, and the ratio of male to female was 1:1. By December 2018, the between births, the average number of litters per fetus and the survival rate of the two groups were counted. There was no significant difference between the two groups in between births and average number of litters per fetus (P>0.05); the survival rate of the experimental group was significantly higher than that of the control group (P<0.01). The application of IVC independent air supply system in the breeding of SCID-Beige mice can significantly improve the survival rate of SCID-Beige mice, thus providing more high-quality experimental animals for animal experiments.

Keywords

SCID-Beige mice, IVC independent air supply system, between births, survival rate