Meta-analysis of the effect of positive thyroid peroxidase antibody on spontaneous abortion in pregnant women
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Yang Zhisen, Liang Xinke, Wang Pengfei, Geng Li
Aim: The effect of thyroid antibody positivity on spontaneous abortion in pregnant women was evaluated by Meta-analysis. Methods: PubMed, The Cochrane Library, China Biology Medicine disc, Chinese sci-tech journal database, China National Knowledge Infrastructure full-text database, and Wanfang academic journal full-text database were searched. (Search until November 20, 2018) Literature on the effect of thyroid antibody positivity on spontaneous abortion in pregnant women was comprehensively searched, methodological quality of the included literature was evaluated, and RevMan 5.3 was used for statistical analysis. Result: A total of 9 articles were included. Meta-analysis results showed that the abortion rate of the experimental group (TPO antibody positive) with normal thyroid function and the control group (antibody negative) was 2.35, 95% CI (1.46, 3.77), with statistically significant difference. While the abortion rate with normal thyroid function and levothyroxine intervention was OR=1.27, 95% CI (0.70, 2.28), and there was no significant statistical difference. Conclusion: The abortion rate of pregnant women with positive TPO antibody was significantly higher than that of women with negative antibody. Levothyroxine intervention did not significantly reduce the risk of miscarriage.
Thyroid antibody positive, abortion, Spontaneous abortion, Meta-analysis