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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Clinical Manifestations and Diagnostic Criteria for Premature Ovarian Failure

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DOI: 10.25236/icbcme.2019.004


Lili Xuan, Xiaojun Liu

Corresponding Author

Xiaojun Liu


To investigate the diagnostic basis of premature ovarian failure (POF) and evaluate the efficacy of sex hormone replacement therapy (HRT). Methods: 50 patients with POF who met the clinical diagnostic criteria were treated with HRT for 3 to 6 cycles. The clinical effects before and after treatment were observed. Vaginal B-ultrasound was used to monitor the dynamic changes of uterus, appendages and serum sex hormone levels. Results: After HRT treatment, patients with menstrual cramps, clinical symptoms were significantly reduced or disappeared. Estrogen levels increased significantly and gonadotropin levels decreased (P < 0.01). After treatment, the endometrium is thickened and the follicles develop well. Conclusion: The status of menopause, low estrogen (E2< 25mg /L) and gonadotropin (FSH > 40IU/L, LH > 30IU/L) before the age of 40 is a clinical diagnostic indicator of POF. HRT is an effective method for the treatment of POF.


Premature Ovarian Failure, Clinical Manifestations, Diagnostic Criteria