Clinical Manifestations and Diagnostic Criteria for Premature Ovarian Failure
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DOI: 10.25236/icbcme.2019.004
Author(s)
Lili Xuan, Xiaojun Liu
Corresponding Author
Xiaojun Liu
Abstract
To investigate the diagnostic basis of premature ovarian failure (POF) and evaluate the efficacy of sex hormone replacement therapy (HRT). Methods: 50 patients with POF who met the clinical diagnostic criteria were treated with HRT for 3 to 6 cycles. The clinical effects before and after treatment were observed. Vaginal B-ultrasound was used to monitor the dynamic changes of uterus, appendages and serum sex hormone levels. Results: After HRT treatment, patients with menstrual cramps, clinical symptoms were significantly reduced or disappeared. Estrogen levels increased significantly and gonadotropin levels decreased (P < 0.01). After treatment, the endometrium is thickened and the follicles develop well. Conclusion: The status of menopause, low estrogen (E2< 25mg /L) and gonadotropin (FSH > 40IU/L, LH > 30IU/L) before the age of 40 is a clinical diagnostic indicator of POF. HRT is an effective method for the treatment of POF.
Keywords
Premature Ovarian Failure, Clinical Manifestations, Diagnostic Criteria