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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Acute Toxicity and Genotoxicity of Perchlorate Based on Flow Cytometry

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DOI: 10.25236/ibmc.2019.037


Hong Xiaoming

Corresponding Author

Hong Xiaoming


Perchlorate is a highly diffusive persistent toxic pollutant, which is widely used in many fields such as missile fuel, fireworks, paint and so on. Perchlorate can induce histopathological changes in the thyroid gland, and at the same time lead to changes in thyroid hormone levels, thereby affecting metabolic activity. Flow cytometry (FCM) is a technique that uses laser beams to stimulate single-line flow of cells to detect their scattered light and fluorescence, thus completing cell analysis and separation. The toxicity of perchlorate was studied in depth and its treatment was studied. The detection technology was comprehensively summarized, and the principle of flow cell usage was described in detail. It is very likely to have toxicity by analyzing the perchlorate concentration. In this study, the acute toxicity and genotoxicity of perchlorate were investigated by the organ coefficient test of each group after small perchlorate exposure. Provide reference for future use of perchlorate, pollution prevention and treatment.


Flow Cytometry, Perchlorate, Toxicity