DCN prevent metastasis of HepG2 cells by elevating the expression of TGF β and P15
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Yanfeng Liu, Xuesong Wang, Wenbo Ju, Dawei Wang
Research shows that DCN prevent the prolifration of human hepa¬toma HepG2 cells and the involvement of transforming growth TGF βsignaling pathway. The results indicated that, cell proliferation was significantly decreased in HepG2 cells transfected with DCN. In addition, DCN transfection significantly increased the phosphorylation level of TGF βRI in HepG2 cells. The expression of the downstream factor p15 was also significantly elevated in the DCN transfected HepG2 cells. In conclusion, DCN elevated the expression level of TGF βRII, increased the phosphorylation level of TGF βRI, enhanced the expression of p15. These findings may contribute to the understanding of the role of DCN in the patho¬genesis of hepatic carcinoma and assist in the disease treatment.
TGF-β, HepG2 cells, DCN, P15, Cell proliferation.