The Effect of Blocking TLR4 Receptor on the Pathogenicity of Escherichia Coli after it infected the Endometrium of Dairy Cow
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DOI: 10.25236/isbsbh.2018.017
Corresponding Author
Lixiang Zhao
Abstract
Based on TLR4 in the innate immune response, it is found that blocking the downstream signal receptor subunit of TLR4 after Escherichia coli infection could significantly reduce the phosphorylation of NF-κB protein as well as the dissociation of I-κB and NF-κB protein, and prevent NF-κB from entering the nucleus and activating related genes factors. Thus, inflammatory cytokines such as TNF-α, IL-1β and IL-6 could not excessively express. After infection, blocking the secretion of inflammatory cytokines initiated by TLR4 showed an outbreak-like response effect, reducing the inflammatory damage caused by excessive secretion of inflammatory cytokines, and had a good protective effect on cells.
Keywords
Escherichia Coli, Endometrium, Toll-Like Receptor 4