Anti-inflammatory Injury Mechanism of Rosuvastatin Calcium on Alzheimer's Disease Model Mice
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DOI: 10.25236/isbsbh.2018.010
Author(s)
Zhongjin Liu, Haiyan Zhang
Corresponding Author
Zhongjin Liu
Abstract
Alzheimer's disease (AD) is a common age-related degenerative disease of the central nervous system. It is characterized by progressive memory impairment, emotional personality and behavioral changes. The pathogenesis is unknown and the treatment effect is not good. With the development of society, the aging of the population is increasing, and the prevalence of AD is gradually increasing. According to the World Health Organization, by 2020, AD will become the fourth disease in China's disease burden. Therefore, raising awareness of AD has great social significance. A number of studies have shown that a large number of activated microglia and astrocytes can be seen around the core and senile plaques (SP) in the brain. Non-steroidal anti-inflammatory drugs can reduce the activation of glial cells and reduce nerves. The damage of the element plays a neuroprotective role. With the deepening of research, most scholars believe that the inflammatory response induced by Aβ deposition is the main mechanism leading to the pathogenesis of AD. How to reduce inflammatory damage becomes an important way to treat AD.
Keywords
Alzheimer Disease, Model Mice, Injury Mechanism, Rosuvastatin Calcium