Author(s)

Liu Yanan, Li Jingyu, Hao Liguo, Xu Dongbing, Zhao Tianyu, Zou He

Corresponding Author

Liu Yanan

Abstract

Objective: Studying the value of fractal analysis method in the diagnosis of benign and malignant breast tumors. Method: 76 cases of patients with breast tumor in our department received from January 2016 to January 2018 are the research objects. Among them, 38 patients are patients of breast cancer, and 38 patients are fibroadenoma of breast. Patients of breast cancer are used as the observation group, and patients of breast fibroadenoma are used as the control group. Based on the fractal characteristics of the tumor morphological structure, the fractal method is used to introduce the fractal dimension into the identification of benign and malignant of breast tumors as an indicator. Two groups of images were preprocessed by MATLAB software to extract tumor boundaries. According to the fractal analysis function of Fraclab toolbox, the fractal dimension of some focus is calculated. The fractal dimension values of the images of the focus in the two groups of patients are calculated and compared. The ROC curve based on the fractal dimension value criteria to identify the sensitivity and the specificity of benign and malignant breast tumors is observed and analyzed. Results: In the mean value of the fractal dimension of the ultrasound focus image, the patients in the observation group were significantly higher than the patients in the control group (P<0.05), and the difference between the two groups is significant. Based on the ROC curve, when using the fractal dimension value 1.90 as the threshold value, and the detecting sensitivity and specificity are both high. Conclusion: The difference of fractal dimension of ultrasound images between benign breast tumors and malignant tumors is obvious. And fractal analysis method is feasible in the differential diagnosis of benign and malignant breast tumors. When the fractal dimension value 1.90 is used as the threshold value, the detecting sensitivity and specificity are both high. The fractal analysis method is of great application value in the differentiation of benign and malignant breast tumors.

Keywords

Tumor of Breast, Differentiation of Benign and Malignant, Fractal Analysis, Application, Value