Author(s)

Feng Chen, Zhen Tian

Corresponding Author

Feng Chen

Abstract

Objective: To investigate the role of γδT cells in pathogenesis by checking the number and apoptosis rate of γδT cells, Vδ1+, Vδ2+ cells in peripheral blood of patients with cardiovascular damage caused by systemic lupus erythematosus. Methods: 45 patients (23 active and 22 inactive) and 22 healthy persons (control group) were selected. The absolute count, percentage and apoptosis rate of γδT cells in active, inactive and control peripheral blood were analyzed by flow cytometry. The absolute counts of Vδ1+ cells and Vδ2+ cells in peripheral blood of active, inactive and control groups were analyzed. Results: The absolute number of peripheral blood γδT cells in active patients was significantly lower than that in inactive patients, and both of them were lower than those in control group. The apoptosis rate of γδT cells in active phase was higher than that in inactive phase and control group. The number of Vδ1+ cells in active phase was lower than that in inactive phase and control group, and the number of Vδ2+ cells in active phase and inactive phase was lower than that in control group. The number of Vδ1+ cell in active phase was more than that in Vδ2+ cell. Conclusion: The number and proportion of γδT cells in peripheral blood of patients with cardiovascular damage caused by systemic lupus erythematosus decreased, and the number of γδT cells and Vδ1+, Vδ2+ subsets in peripheral blood of patients with systemic lupus erythematosus were abnormal. Apoptosis of γδT cells in peripheral blood of patients with cardiovascular damage caused by systemic lupus erythematosus increased, resulting in overexpression of cells and disorder of immune system.

Keywords

γδT Cells, Systemic Lupus Erythematosus, Cardiovascular Damage, Clinical Significance