Author(s)

Xing’E Hu, Xiaoxiao Yu

Corresponding Author

Xing’E Hu

Abstract

Objective: To study the clinical effect of Tianmeng capsule and paroxetine in the treatment of menopausal women with generalized anxiety disorder. Methods: 63 climacteric patients with generalized anxiety disorder were selected from January 2017 to December 2017. The patients were divided into the control group and the observation group by random number table method, with 63 cases in each group. Patients in the control group were treated with paroxetine, while patients in the observation group were treated with paroxetine and Tianmeng capsule. The difference between the two groups was compared after 1 months of continuous treatment. Results: After treatment, the PSQI and HAMA scores of the two groups were significantly lower than those before treatment (P < 0.05). After treatment, the PSQI and HAMA scores of the observation group were significantly lower than those of the control group (P < 0.05). The total curative effect rate of the observation group was 93.65%, and that of the control group was 84.13%. The difference between the two groups was statistically significant (P < 0.05). FSH and LH levels after treatment were significantly lower than those before treatment (P < 0.05), and E2 levels were significantly higher than those before treatment (P < 0.05). After treatment, there was no difference in FSH, LH and E2 between the two groups (P>0.05). After treatment, the levels of SOD and MDA in the two groups were significantly higher than those before treatment (P < 0.05) and lower than those before treatment (P < 0.05). After treatment, the SOD of the observation group was significantly higher than that of the control group (P<0.05), and MDA was significantly lower than that of the control group (P<0.05). The rate of adverse reactions in the control group was 25.40%. The rate of adverse reactions in the observation group was 0.00%. There was a significant difference between the two groups (P < 0.05). Conclusion: Paroxetine combined with Sweet Dream Capsule is effective in the treatment of menopausal women with generalized anxiety disorder, with fewer adverse reactions and high safety. It is worthy of clinical promotion

Keywords

Generalized Anxiety Disorder, Tianmeng Capsule, Menopause, Paroxetine, Sex Hormones, Oxidative Stress