Author(s)

Shanshan Sun, Huiyun Wang, Lin Ding, Xiangao Quan, Yanzhi Li

Corresponding Author

Huiyun Wang

Abstract

Objective: To explore the interactions between various components of novel non-ionic surfactant vesicles, to prepare better vesicle system with higher quality and higher encapsulation efficiency, this study investigated the interactions among non-ionic Gemini surfactants, polyethylene glycol, and various drugs. Methods: Different concentrations of Gemini non-ionic surfactant solution and its mixed system with polyethylene glycol, methotrexate and olmesartan ester were prepared, and the relationship between surface tension, particle size, and potential and concentration was determined. Results: Tension measurements showed that the critical micelle concentration of Gemini surfactant was 0.5% ~ 0.7%; 0.01% ~ 1.0% of PEG-6000 and 0.05% ~ 0.3% of methotrexate (mass concentration) have no effect on the surface tension of the Gemini surfactant solution. Olmesartan ester (0.01% ~ 0.25%, mass concentration) may decrease the surface tension of the solution. Measurement results of both the particle size and the electronic potential show that there are inflection points at concentrations of 0.5% ~ 0.7%. Conclusion: Using surface tension method and measurement of particle size and electronic potential, it can be concluded that PEG-6000 and methotrexate have no interaction with Gemini surfactants; olmesartan ester can decrease the surface tension of the solution, so better effects may be obtained if it is mixed with Gemini surfactants.

Keywords

Gemini Non-Ionic Surfactant, Polyethylene Glycol, Methotrexate, Olmesartan Ester, Surface Tension, Particle Size, Electronic Potential