Author(s)

Changlei Li, Huiling Yi, Xiaoqing Chen, Baomiao Ma

Corresponding Author

Baomiao Ma

Abstract

To investigate the effects of Polysaccharide MDG-1 from Ophiopogon japonicus on glucose and blood lipid, insulin resistance and the levels of inflammatory factors in T2DM rats. The T2DM rat model induced by intravenous injection small dosage of streptozotocin(STZ) and feeding high fat-high glucose diet. The rats whose glucose level≥11.1mmol•L-1 were randomly divided into 5 groups(n=10 in each): model group, glibenclamide group, Polysaccharide MDG-1 from Ophiopogon japonicus of high dose, medium dose and low dose. Five weeks later, to detected the FBG, blood lipid, TG, CHOL, HDL-C and LDL-C, INS, TNF-α and CRP in the serum were detected by the method of radioactive immunoassay, and accordingly INS and FBG, the insulin resistance indexes (HOMA-IR) were figured out. Compared with model group, the FBG and TG level in rats of high dose group of MDG-1 could were decreased with significantly, and the levels of INS and HOMA-IR were decreased, HDL was increased. The levels of TNF-α, CRP in the serum were significantly down-regulated in high dose group of MDG-1. Polysaccharide MDG-1 from Ophiopogon japonicus can decrease glucose, blood lipid and improve insulin resistance in T2DM rats by decreasing the levels of inflammatory factors of TNF-α and CRP.

Keywords

Polysaccharide Mdg-1 From Ophiopogon Japonicus, Type 2 Diabetic Mellitus(T2Dm), Glucose, Blood Lipid, Insulin Resistance, Inflammatory Factors