Author(s)

Duhong Xie, Wenliang Lu, Zicong Wu, Zhiping Wang

Corresponding Author

Duhong Xie

Abstract

This work aims to develop carbomer (934,0.25%) loaded Puerarin nanosuspension hydrogel (Pue-NH) as a novel dermal formulation. Pue nanosuspension were prepared by high pressure homogenization technique, applying 1500 bar up to 15 cycles. The long-term storage stability of Pue-NH was studied after stored at room temperature for 90 days. The physicochemical characteristics of Pue-NH were conducted and used to evaluate the stability. The results showed that the particle size, polydispersity index (PDI) and zeta potential (ZP) were 218.5 nm and −18.81 mV, respectively. After three months of storage, the Pue-NH showed no significant changes in particle size and PDI except a miner change in ZP. These results demonstrate that particle size could be a promising formulation for enhanced pharmacological activity of Pue and were stable at room temperature.

Keywords

Nanosuspension, Hydrogels, Puerarin, Stability, Long-Term Storage