The best way to conference proceedings by Francis Academic Press

Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

The Preparation and Long-term Storage Stability of Carbomer-loaded Resveratrol Nanoethosomes Hydrogels

Download as PDF

DOI: 10.25236/iccse.18.015

Author(s)

Zicong Wu, Duhong Xie, Wenliang Lu, Zhiping Wang

Corresponding Author

Zhiping Wang

Abstract

This work aims to develop carbomer (934,0.25%) loaded resveratrol nanoethosomes hydrogel (Res-NH) as a novel dermal formulation. Res nanoethosomes were prepared by high pressure homogenization technique, applying 1500 bar up to 15 cycles. The long-term storage stability of Res-NH was studied after stored at room temperature for 90 days. The physicochemical characteristics of Res-NH were conducted and used to evaluate the stability. The results showed that the particle size(PS), polydispersity index(PDI) and zeta potential(ZP) were 101.9±6.7nm, 0.249±0.121 and −19.91±1.39 mV, respectively. After three months of storage, the Res-NH showed no significant changes in particle size and PDI except a miner change in ZP. These results demonstrate that particle size could be a promising formulation for enhanced pharmacological activity of Res and were stable at room temperature.

Keywords

Nanoethosomes, Hydrogels, Resveratrol, Stability, Long-Term Storage