Author(s)

Matthew Krivacka Kay, Mingxin Ma

Corresponding Author

Matthew Krivacka Kay

Abstract

Nano-drug delivery system is of great significance in the field of modern medical drug delivery, and its intelligent optimization and biocompatibility evaluation are the key research directions. This paper discusses the intelligent optimization strategy and the evaluation method and index of biocompatibility around nano-drug delivery system. The intelligent optimization strategies such as environmental response, targeted modification and intelligent controlled release are expounded. With the help of cytotoxicity in vitro, blood compatibility evaluation, animal model experiment in vivo and toxicity evaluation of tissues and organs, the influence of intelligent optimization on biocompatibility was studied. Taking the nano-drug delivery system based on pH response and targeted modification as an example, the results showed that the survival rate of HepG2 cells was 85% when its in vitro concentration was 10 μg/mL. The hemolysis rate was 3%. In vivo experiments, the high-dose group showed mild inflammatory cell infiltration in the liver, and some blood biochemical indexes changed. It is not difficult to see from the research results that intelligent optimization can improve the performance, but the biocompatibility still needs to consider many factors to ensure safety.

Keywords

Nano-Drug Delivery System; Intelligent Optimization; Biocompatibility; Appraisal Procedure