Author(s)

Yicheng Xiong

Corresponding Author

Yicheng Xiong

Abstract

Chronic myeloid leukemia (CML) is a malignant neoplasm marked by the abnormal clonal expansion of hematopoietic stem cells within the bone marrow. Emerging therapeutic modalities, such as im-munotherapy, have shown promise in the management of CML. This approach involves the activa-tion or enhancement of the patient's immune system to effectively identify and target cancerous cells. This review aims to elucidate the diverse applications of immunotherapy in the treatment of CML. Notably, dendritic cell (DC) vaccines and leukemia-associated antigen (LAA) tumor vaccines show promise in eliciting specific immune responses against CML tumor antigens. Additionally, al-logeneic stem cell transplantation (Allo-SCT) and donor lymphocyte infusion (DLI), as traditional and significant immunotherapeutic strategies, offer crucial treatment options for patients with mul-ti-line tyrosine kinase inhibitor (TKI) resistance and those in the blast phase of CML.

Keywords

chronic granulocytic leukemia (CML), immunologic principles, immunotherapy, immunotherapy de-velopment