Application of CRISPR-Cas9 Technology in the Treatment of Metabolic Diseases
Download as PDF
DOI: 10.25236/icetmr.2024.009
Corresponding Author
Ziyi Li
Abstract
Since its development, CRISPR-Cas9 technology has demonstrated significant potential for the research and treatment of metabolic diseases. This article first outlines the basic principles of CRISPR-Cas9 technology and its specific applications in the treatment of metabolic diseases. The application examples of this technology in the research of fat metabolism, obesity and diabetes in vivo, as well as its innovative progress in the transformation of zebrafish models with metabolic diseases, were discussed in detail. As a result of these applications, new insights into the pathogenesis of metabolic diseases have been gained, as well as a foundation for developing new treatment strategies has been laid. However, the application of CRISPR-Cas9 technology also faces some challenges, especially in terms of safety and ethics. Gene editing poses a number of safety, ethical, and legal issues, and norms and standards are being developed to ensure its responsible application. A final consideration in this article is to anticipate the direction in which CRISPR-Cas9 technology will develop in the future for the treatment of metabolic diseases, emphasize the need to continue exploring its potential applications, and anticipates that it will improve human quality of life and promote health.
Keywords
CRISPR-Cas9 technology; Metabolic diseases; Disease treatment; Ethical issues