Author(s)

Yaping He, Haiyan Peng

Corresponding Author

Haiyan Peng

Abstract

Colorectal cancer, a prevalent condition, has garnered significant scientific and clinical focus. In the past few years, autophagy—a pivotal cellular process facilitated by molecular partners—has become a research hotspot due to its critical role in colorectal cancer's progression, therapeutic responses, and drug resistance. This article reviews advances in understanding the interplay between autophagy and colorectal cancer, highlighting promising future research avenues. Initially, we delve into the roles played by molecular chaperones, specifically HSP70, HSP90, and CHIP, in colorectal cancer biology. Subsequently, we underscore the significance of autophagy in colorectal cancer treatment paradigms. Lastly, we explore future research prospects, such as the tailoring of personalized treatment strategies, the development of drugs that modulate autophagy, and the translation of these research findings into clinical practice. The intersection of molecular chaperone-mediated autophagy and colorectal cancer research represents a dynamic and rapidly evolving field. By deepening our understanding of the interplay between molecular chaperones and autophagy, we anticipate developing more effective therapeutic strategies, thereby enhancing outcomes for patients with colorectal cancer and expanding their health and survival prospects.

Keywords

colorectal cancer; autophagy; molecular chaperone