Author(s)

Junfeng Guo, Qiong Yin, Qiang Fu

Corresponding Author

Qiang Fu

Abstract

The purpose of this study is to explore the synthesis of gold nanoparticles from Ginkgo biloba extract and its antitumor effect on nasopharyngeal carcinoma cells in vitro. In this paper, the method of reducing chloroauric acid with Ginkgo biloba extract was adopted, and the preparation conditions were systematically optimized, including the ratio of Ginkgo biloba extract to chloroauric acid, reaction temperature and reaction time. The particle size and stability of gold nanoparticles were characterized by transmission electron microscope and dynamic light scattering. In addition, the effect of gold nanoparticles on the viability of nasopharyngeal carcinoma cells was evaluated, and its possible mechanism was discussed by flow cytometry and protein blot. In vitro experiments proved that the nano-gold synthesized from Ginkgo biloba extract had anticancer effect on nasopharyngeal carcinoma cells, which provided potential drug candidates for the treatment of nasopharyngeal carcinoma. It provides a new research direction for the application of Ginkgo biloba extract and nano-gold in biomedical field.

Keywords

Ginkgo biloba extract; Nanogold; Nasopharyngeal carcinoma cells; Anti-cancer effect