Author(s)

Xuelin Wang, Fei Sun, Xuelin Wang

Corresponding Author

Xuelin Wang

Abstract

Peripheral arterial disease (PAD) is a major manifestation of peripheral atherosclerosis. Murine hind limb ischemic (HLI) model is widely used to study the appropriate treatment to treat PAD. Currently, there are multiple strategies developed for vascular regeneration, validated through HLI model. However, limited publications have offered the in-depth analysis of the therapeutic effects among all these treatments. Here, we handpicked four different therapies (nano-therapy, gene knockout therapy, drug therapy and adenovirus therapy) for the treatments of hindlimb ischemic disease and compared their RNA-Seq data to elaborate the common activation genes and pathways in vascular regeneration. We found that different treatments can activate similar pathways related to angiogenesis, further promote related biological processes, and achieve the purpose of angiogenesis.

Keywords

hindlimb ischemia, gene therapy, nanotherapy, adenoviral therapy, drugs