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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Study on the Mechanism of Histone Methyltransferase G9a Inhibiting Liver Tumor Cell Proliferation based on Medical Big Data

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DOI: 10.25236/icceme.2023.010


Pang Chi, Yao Hongbo, Li Xingmei, Che Liqun, Farra Aidah Jumuddin

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Farra Aidah Jumuddin


While medical informatization has received unprecedented attention and development, there are also many problems in medical informatization due to the arrival of the big data era and the relatively backward development of traditional medical information technology. Medical big data will play a huge role in clinical decision-making assistance, medical quality supervision, disease prediction models, clinical trial analysis, personalized treatment and other medical services. This article investigates the mechanism of histone methyltransferase G9a inhibiting liver tumor cell proliferation based on medical big data. The occurrence of liver tumors was previously believed to be the result of mutations in tumor suppressor genes and oncogenes. Recently, more and more studies have shown that epigenetic regulatory mechanisms of gene expression, such as abnormal DNA and histone modifications, play a crucial role in tumor development. Compared with non cancerous tissues of liver cancer patients, the expression of G9a in liver cancer tissue is significantly increased, and knocking out the G9a gene can significantly inhibit the growth and invasion and metastasis of liver cancer cells, indicating a correlation between G9a and the occurrence of liver cancer.


Medical big data; Histone A; G9a; Liver tumors; Cell proliferation mechanism