Transplantation of Neural Stem Cells and Peripheral Blood Endothelial Progenitor Cells in the Treatment of Ischemic Cerebrovascular Diseases
Download as PDF
Wen JIANG, Song MEI, Chunyan Lei
Objective: To investigate the effect of transplantation of neural stem cells and vascular endothelial progenitor cells on ischemic cerebrovascular diseases. Methods: 120 SD rats were randomly divided into observation group and control group. In the observation group (n = 60), the cerebral ischemia model was established by suture-occluded method in SD rats, and neural stem cells and peripheral blood endothelial progenitor cells were transplanted. The control group was treated with conventional drugs (n = 60). The clinical effects, hemorheology and serum inflammatory factors before and after treatment were compared between the two groups. Results: ①After transplantation, the clinical effect of the observation group was higher than that of the control group (P < 0.05); ②After treatment, the whole blood viscosity, plasma viscosity, fibrinogen and hematocrit of the two groups decreased (P < 0.05), and the observation group was lower than that of the control group (P < 0.05); ③Serum homocysteine (HCY), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor -α(TNF-α)and the level of neuron specific enolase (NSE) after treatment in the observation group was lower than that in the control group (P < 0.05). Conclusion: Transplantation of neural stem cells and vascular endothelial progenitor cells is effective in the treatment of ischemic cerebrovascular diseases. It can effectively regulate serum inflammatory factors and improve hemorheology (P < 0.05), which has significant curative effect on ischemic cerebrovascular diseases.
Stem cells, Peripheral blood endothelial progenitor cells, Transplantation, Ischemic cerebrovascular diseases