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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Study on the Association and Intervention of Personality Trait Gene Polymorphisms and Mci Elderly People

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DOI: 10.25236/iwass.2021.043


Qiang Li, Xiumei Ma, Deshui Liu, Yingyan Zhang, Yin Gao, Guiling Li, Xuewen Yang, Yuexian Ma, Wei Liu, Hongjuan Wei

Corresponding Author

Hongjuan Wei


To explore the effects of single genes and interactions of Stin2, 5-HTTLPR, NET T-182C, and NET G-1287A on Eysenck personality traits in healthy Chinese Han population. Methods: Strictly follow the enrollment criteria to screen 367 healthy Chinese Han people, collect general demographic data, use the Eysenck Personality Questionnaire (EPQ) to measure the three dimensions of personality N, E, and P, and calculate the standard score (T) for each dimension , And divided by T50, each dimension is divided into two levels: neurotic and non-neurotic personality, introverted and extraverted personality, psychotic and non-psychotic personality; polymerase chain reaction (PCR) detection of Stin2, 5-HTTLPR, NET T-182C, NET G-1287A gene polymorphism. Use SPSSl3.0 statistical software for unit point data analysis: t-test, variance analysis to compare personality differences between genotypes and alleles, f-test to analyze the distribution differences of genotypes and alleles among personality dimension classes; use UNPHASED software Calculate the Global P value; use the MDR Software package to analyze the interaction among the genotypes of Stin2, 5-HTTLPR, NETT-182C, and NET G-1287A.


Trait gene polymorphisms, Mci elderly people, Personality trait