Author(s)

Wei Zhou, Hui Huang

Corresponding Author

Wei Zhou

Abstract

Objective: to observe and analyze the clinical effect of alendronate combined with functional exercise on degenerative Osteoarthrifis(OA), so as to provide an effective scheme for its clinical treatment. Methods: A total of 60 cases of degenerative OA patients in our hospital were selected as the research object, and they were randomly divided into the group A and the group B, with 30 cases in each group. Patients in the group A were orally administrated with alendronate, while those in the group B were given functional exercise therapy in combination with alendronate as the group A. Results: After treatment, VAS score of group B was obviously superior to that of group A, and the differences were statistically meaningful (t=2.41, P < 0.05). After intervention, the levels of serum P1NP and CTX in the two groups were meaningfully lower than those before intervention (P < 0.05), and the levels of BGP and 25(OH)D were meaningfully higher than those before intervention (P < 0.05). After the treatment within the same period of time, the effective rate of patients in the group B in comprehensive treatment was 93.8%, meaningfully higher than 79.7% in the group A (P < 0.05). Conclusion: For degenerative OA, alendronate combined with functional exercise has a more meaningful effect, which can further improve the stiffness of the affected parts of the limbs, reduce the degree of pain, and improve the quality of life of patients.

Keywords

Alendronate sodium, Functional exercise, Degenerative OA, Clinical effect