Author(s)

Xianghua Sun, Yali Wang

Corresponding Author

Xianghua Sun

Abstract

Objective: To investigate the effect of enteral and parenteral nutrition on gastrointestinal hormone levels in patients after gastric surgery. Methods: Fifty-eight inpatients undergoing subtotal gastrectomy were selected for clinical study. Urinary urea nitrogen, urinary creatinine, fasting serum albumin, plasma motilin (MTL) and cholecystokinin (CCK) levels were measured in the early morning of 2,4 and 8 days after admission. Results: Serum Alb, Prealb and TFN in parenteral nutrition group and enteral nutrition group increased significantly after nutrition support (P < 0.05), while the two measured values in control group had no significant change. The number of normal electrogastrogram in 38 patients before operation was 25, accounting for 65.8%; The number of patients with abnormal gastric electricity was 13, accounting for 34.2%. Plasma MTL level in enteral nutrition group was significantly higher than that in parenteral nutrition group on the 4th and 8th day after admission (P < 0.05). On the 8th day after admission, CCK level in enteral nutrition group was significantly higher than that in parenteral nutrition group (P < 0.05). Conclusion: The levels of gastrin and motilin in patients with gastric cancer are significantly higher than those in normal people, and tend to increase gradually with the development of pathological stages of gastric cancer. The application of enteral nutrition after gastric surgery can increase the level of plasma cholecystokinin, promote the contraction of gallbladder and prevent the occurrence of gallbladder diseases such as cholestasis.

Keywords

Enteral nutrition, Parenteral nutrition, Motilin, Gastrointestinal hormone, stomach cancer