Antiviral Efficacy and Influencing Factors of Hcv Recurrence after Liver Transplantation
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Kepu Zheng, He Fang, Yingpeng Zhao, Yizhou Jiang, Jianghua Ran
Objective: To analyze the antiviral efficacy and influencing factors of HCV recurrence after liver transplantation. Methods: 42 patients with HCV recurrence after liver transplantation in our hospital from February 2020 to February 2021 were retrospectively selected, and the clinical efficacy of different treatment methods was statistically analyzed. Results: Among the 21 patients, 16 (76.2%) got etvr, and the other 5 patients who didn't get etvr were treated for less than 3 months. Among the 16 patients with etvr, 11 patients had virus rebound after drug withdrawal, and 5 patients (23.8%) had SVR. Etvr was obtained in both standard treatment and foot course treatment, and in incomplete treatment, etvr was obtained in 7 cases, but there was no significant difference among the 3 groups (P > 0.05). SVR was obtained in 4 cases of standard treatment, 1 case of foot treatment, and no case of incomplete treatment. The difference was statistically significant (P < 0.05). There were significant differences in viral load and treatment plan between the two groups, indicating that viral load before treatment and the dose and course of antiviral drugs were important factors affecting the SVR (P < 0.05). In the course of antiviral treatment, the patients had fever and influenza like symptoms, joint discomfort and loss of appetite, but they were tolerable and did not affect the treatment. Twenty patients had to use G-CSF to maintain antiviral therapy due to neutropenia, and two patients developed autoimmune hepatitis at the end of treatment. The reasons for discontinuation were rejection (4 cases), severe neutropenia (4 cases), biliary complications (4 cases), decreased hemoglobin (2 cases), extreme fatigue (2 cases), skin healing (2 cases), skin pain and itching (2 cases), infection (2 cases) and self discontinuation (2 cases). After stopping antiviral treatment and giving corresponding symptomatic treatment, the symptoms of all patients were eliminated and the biochemical indexes were improved. Conclusion: The antiviral effect of HCV recurrence after liver transplantation is significant. The influencing factors are the viral load before treatment, the dose and course of antiviral drugs.
After liver transplantation, Hcv relapse, Antiviral, Curative effect, Influence factor