Author(s)

Chen Jing, He Limei, Liu Yu, Zhu Jie, Shen Zonglin

Corresponding Author

Shen Zonglin

Abstract

Depression is a disease mainly clinically characterized by persistent low spirits, accompanied by mental retardation, loss of interest, cognitive impairment and related physical discomfort, such as sleep disorders, fatigue, loss of appetite and other symptoms. In this study, we discuss the cognitive deficits of depression from the perspective of brain imaging genetics of mental retardation and cognitive impairment in depression, and illustrate the abnormal macro-brain activity and micro-molecular markers behind the cognitive deficits. In future research, genetic and neuroimaging methods should be expanded, emphasis should be placed on the measurement of environmental factors, and the pathological model of depression should be constructed by integrating genetic, neuroimaging and environmental variables. Furthermore, the subtypes of depression were classified, providing a scientific basis for in-depth understanding of the pathogenesis of depression and individualized diagnosis and treatment.

Keywords

Depression; Mental retardation; Cognitive impairment; Brain imaging genetics