A Novel Therapeutic Mechanism for Bacterial Vaginitis Based on Gentian Liver-Draining Decoction and Its Modified Prescription Combined with Sophora Flavescens Gel
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Haonan Zhu, Weiqi Chen, Xijian Guo, Ningxin Liang, Xinyi Ma, Peizheng Yan, Dong Yu
Objective: a novel therapeutic mechanism using gentian liver-draining decoction and its modified prescription as a guide formula, combined with Sophora flavescens gel and chitosan, for the treatment of bacterial vaginitis is is proposed. Method: the variation of TNF-α and IL-1β contents and the degrees of ICAM-1 and VCAM-1 expression before and after the use of the novel therapeutic mechanism were examined by multiple bacteriostatic tests and tube double decreasing dilution method. Results: the novel therapeutic mechanism effectively reduced the content changes of TNF-α and IL-1β, and reduced the high expression of ICAM-1 and VCAM-1. It can also inhibit the reproduction of anaerobic bacteria such as staphylococcus aureus in the vagina, maintain the vaginal pH value and the stability of the ecological environment of bacteria, prevent the imbalance of the micro ecosystem in the vagina, and reduce the incidence probability of bacterial vaginitis.
Bacterial vaginitis; Sophora flavescens gel; Modified Gentian liver-draining decoction; Syndrome of dampness-heat of liver channel