BCG Polysaccharide Nucleic Acid Interferes with the Mechanism of PHN Mediated by Inflammatory Factors
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Di WU, XingNan Li, Xiufe Wang, Hao XU, Yuehua Ma, Shukun Lv, Liran Cui
To investigate the effect of BCG polysaccharide nucleic acid on pain and inflammatory factors of postherpetic neuralgia (PHN)METHODS: The included patients were randomly divided into the conventional treatment group and BCG-PSN group. Both groups were given conventional pain treatment. BCG-PSN group was treated with BCG-PSN nucleic acid. To observe and compare the changes of quality of life (QOL), visual analogue score (VAS), SP, inflammatory factors interleukin-1 Settings (il-1 Settings), interleukin-6 (il-6), interleukin-10 (il-10), and record the adverse reactions [RESULTS]: VAS and QOL scores after treatment showed that the pain symptoms of each group were significantly alleviated and the quality of life was good. The concentration of SP, the pain substance, was decreased by radioimmunoassay, and the expression levels of il-1 and il-6 and il-10 were significantly decreased by ELISA. The improvement of bcg-psn group was more likely to healthy people than the conventional treatment group (P<0.05). [CONCLUSION]: BCG-PSN can effectively reduce the neuroinflammatory pain response of PHN and relieve pain. The mechanism may be to improve the expression of serum inflammatory factors and regulate the local inflammatory environment caused by chronic pain.
BCG-Polysaccharide Nuceic Acid; Postherpetic Neuralgia; inflammatory factor; P-substance