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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Research Progress of Nrf2 Signaling Pathway on Diabetic Nephropathy

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DOI: 10.25236/icmbmm.2018.67


Jingbo Li

Corresponding Author

Jingbo Li


The transcription factor NF-EZ-related factor 2 (NF-EZ-erlated factor Z, N-argument) is an important transcription factor that regulates oxidative stress in vivo and is a central regulator of cellular anti-oxidation and repression. N-curd is activated by interaction with antioxidant response elements. The Nrf2 A/RE pathway, which reduces reactive oxygen species produced by high-glucose factors, exerts its anti-oxidative stress-damaging and anti-chronic inflammatory responses, and improves oxidative stress-induced insulin resistance, and a defense mechanism plays a very important role in diabetic macrovascular and microvascular complications.


Nrf2 signaling pathway, Diabetic nephropathy, Advances.