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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Secrum microRNA-122 with HCC in chronic hepatitis C

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DOI: 10.25236/icmbmm.2018.63


Qian Zhang, Yonggui Zhang, Ping Zhao, Jian Jiao, Jiangbin Wang, Wenqian Qi

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Qian Zhang


To evaluate the correlation of secrum microRNA-122 with hepatocellular carcinoma, serum samples were obtained from 50 patients with hepatocellular carcinoma and 50 age-matched and sex-matched chronic HCV volunteers. miRNAs were isolated from the serum samples. Expression of miRNA-122 in cases and controls was quantified using U6 sn RNA as the internal control. Results show that the serum miRNA-122 level in patients with hepatocellular carcinoma was significantly reduced in comparison with controls and correlated with known risk factors for hepatocellular carcinoma. The serum miRNA-122 of late stage were significantly higher than the one of early stage. HCC patients with low miRNA-122 expression were correlated with lower survival in patients compared with those with higher miRNA-122 expression. Therefore, the serum miRNA-122 level correlates with risk factors for hepatocellular carcinoma. MiRNA-122 may be as a potential diagnostic tool for hepatocellular carcinoma. Further analysis is needed to evaluate the diagnostic power of miRNA-122 for hepatocellular carcinoma.


Circulating miRNA, miRNA-122, Hepatocellular carcinoma, Molecular diagnostics.