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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Clinical and Pathological Features of C3 Glomerulonephritis

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DOI: 10.25236/icmbmm.2018.53


Qi Jiang, Yingying Liu

Corresponding Author

Yingying Liu


The clinical manifestations and pathological features of C3 glomerulonephritis were analyzed in order to provide some references for the clinical diagnosis and treatment of C3 glomerulonephritis. The paper selected 60 cases of C3 glomerulonephritis from January, 2015 to December, 2017 in China-Japan Union Hospital of Jilin University selected for clinical study. According to the clinical data, the clinical manifestations and case characteristics of the patients were statistically analyzed. In a word. there were 20 cases with the first symptom of hematuria, 40 cases with hematuria and proteinuria as the first symptom, 30 cases of nephritic syndrome, 10 cases of nephrotic syndrome and 60 cases of child complement C3 decreased and the complement C4 was normal. The positive deposition of complement C3 was observed in 60 children with immunofluorescence; there were 50 cases of Mesangial proliferative glomerulonephritis and 10 cases of endocapillary proliferative glomerulonephritis under light microscope; electron dense deposit was found in 30 cases under electron microscope, and no electron dense deposit was found in 30 cases. The routine treatment of nephritis was given, and 2 crescent forming patients were treated with glucocorticoid. All patients with C 3 glomerulonephritis were followed up for 6 to 42 months and the prognosis was good. To sum up, in children with C3 glomerulonephritis, hematuria and (or) proteinuria was the main manifestation. Immunofluorescence was found in C3 strongly positive deposition. The light microscopy showed that mesangial proliferative glomerulonephritis was dominant, and electron microscopy showed electron dense deposit and short-term prognosis.


C3 glomerulonephritis, Clinical manifestation, Case features, Clinical value.