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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Research Progress on the Occurrence Mechanism of Renal Interstitial Fibrosis

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DOI: 10.25236/icmbmm.2018.52


Qi Jiang, Yingying Liu

Corresponding Author

Yingying Liu


Renal fibrosis refers to the increase of interstitial cells and interstitial cells under various pathogenic factors such as inflammation, injury and drugs, especially the increase of matrix protein synthesis, and the suppression of matrix degradation resulting in extracellular matrix ECM) caused a large accumulation of glomerular sclerosis and tubulointerstitial fibrosis. It is a common pathological manifestation of renal disease progression to end-stage renal failure. The current study confirms that the correlation between renal interstitial fibrosis and renal dysfunction, which is more closely related to glomerulosclerosis and renal dysfunction. To further study the molecular mechanism of renal interstitial fibrosis and explore effective prevention and treatment measures is of great significance for delaying the progression of end-stage renal disease (ESRD) and prolonging the life of patients.


Research Progress, Occurrence Mechanism, Renal Interstitial.