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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Study on the Mechanism of Renal Interstitial Fibrosis

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DOI: 10.25236/icmbmm.2018.02


Qi Jiang, Yingying Liu

Corresponding Author

Yingying Liu


Interstitial fibrosis (RIF) refers to the pathological process of the kidney caused by a variety of damaging factors characterized by significant proliferation of fibroblasts within the interstitium and excessive deposition of extracellular matrix. RIF is the terminal stage of chronic kidney disease, the prognosis is poor; therefore, in-depth understanding of the formation mechanism of RIF to guide its prevention and treatment is of great significance. For a long time, epithelial-mesenchymal transition (EMT) is considered as an important cause of RIF. However, some scholars have put forward different opinions that EMT has nothing to do with renal interstitial fibrosis, Pericytes-mesenchymal transition and interstitial microvascular thinning are closely related.


RIF, Mechanism, Medical Issue.