Osteogenic Effect of Ti02 Nanotube BMP2 / BMP7 Composite Layer on Titanium Implant Surface
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Xiaolong Ma, Zebiao Kang, Xiaoxue Mai, Weibo Jie, Fuqiang Xie
As we all know, titanium is a metal with many advantages. Titanium and titanium alloys have been widely used in medical artificial joint prosthesis materials because of their excellent mechanical properties, biocompatibility and corrosion resistance. However, due to the inertia of titanium, titanium can not directly combine with bone. The surface modification of titanium implants is one of the research hotspots of implant materials. In this paper, the osteogenic effect of Ti02 nanotube BMP2 / BMP7 composite layer on titanium implant surface was studied. In this study, we prepared TiO2 nanotubes by anodic oxidation method. Eight rats were selected as the research animals, and they were randomly divided into the control group and the experimental group. The femoral implants of rats were implanted into the model for in vivo research. The control group used the general titanium implant, and the experimental group used the modified surface with Ti02 nanotube BMP2 / BMP7 composite layer Titanium implants. We compared and analyzed the histological morphology, bone mineral density, bone implant contact area and bone tensile strength. In this study, we found that the average BMD of the femur of the control group was 124.28mg/cm2, and that of the experimental group was 375.36mg/cm2. It can be seen that the femoral density of the experimental group is much higher than that of the control group. The experimental results show that the composite layer of Ti02 nanotube BMP2 / BMP7 on the surface of titanium implant has good osteogenic effect.
Titanium Implant, Ti02 Nanotube, BMP2 / BMP7 Composite Layer, Surface Modification, Bone Mineral Density