Synthesis of 4-((7-methoxy-6-nitroquinazolin-4yl) oxy) aniline
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Meng Liu, Yiling Zhang, Fang Yuan, Mia Liao, Yao Zeng, Shan Xu
4-((7-methoxy-6-nitroquinazolin-4-yl) oxy) aniline, is common to find in the synthesis process of many antitumor drugs. An efficient synthetic method with high yield for compound 9 was established in this work. The target product was synthesized from 7-fluoro-6-nitroquinazolin-4-ol (5) through three steps including chlorination and nucleophilic substitution reactions. The structure of the compound 9 was confirmed by 1H NMR and MS spectrum and the total yield of the three steps was high up to 61.7%.
4-((7-methoxy-6-nitroquinazolin-4-yl) oxy) aniline, Synthesis