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Web of Proceedings - Francis Academic Press

Regulation of ATP Flow by Calcium Sensitive Receptors in Diabetic Cardiomyopathy

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DOI: 10.25236/wccbm.2020.050


Libo Wen, Hongbo Yao, Bin Wang, Fanmou Meng, Mingxi Ni, Kun Zhao

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Libo Wen


Diabetes mellitus (DM) is a common disease that seriously endangers people's health. Diabetic patients are prone to complicated cardiomyopathy or heart failure, which has become an important cause of death for diabetic patients. Diabetic cardiomyopathy (DCM) is a specific cardiomyopathy, which is mainly caused by cardiac microvascular disease and myocardial metabolic disorder due to hyperglycemia. It is characterized by left ventricular hypertrophy and diastolic dysfunction with or without systolic dysfunction. The specific pathological changes of diabetic cardiomyopathy is one of the common hidden cardiovascular complications of diabetes. Its clinical manifestations include heart failure, angina pectoris and arrhythmia, and it can exclude cardiomyopathy caused by hypertension, coronary heart disease, heart valve disease and other heart diseases. It is of great significance to study the pathogenesis of diabetic cardiomyopathy for the prevention and treatment of diabetes and its cardiovascular complications. Based on this, this paper analyzes the role of calcium sensitive receptors in the regulation of ATP flow in the pathogenesis of diabetic cardiomyopathy.


Diabetic cardiomyopathy, Metabolic disorders, Pathogenesis