Author(s)

Zhiqiang Sun, Qingxiu Wang

Corresponding Author

Zhiqiang Sun

Abstract

Objective To observe the effect of Dexmedetomidine intranasal drop on induction compliance, emergence delirium and post hospitalization behavior change in children undergoing laparoscopic high ligation for incarcerated inguinal hernia.Methods Ninety children undergoing laparoscopic high ligation for incarcerated inguinal hernia were randomly divided into 3 groups: dexmedetomidine group 1 (Group D1), dexmedetomidine group 2 (Group D2), and control group (Group C),with 30 cases in each group. 30 minutes before anesthesia induction, Group D1 received dexmedetomidine intranasal drop 1 μg•kg-1, Group D2 received dexmedetomidine intranasal drop 2 μg•kg-1, Group C received normal saline. ICC score, PAED score, PHBQ case, MAP,HR,SpO2 and adverse reaction were recorded. Results Compared with T0 and group C,group D1,MAP and HR in group D2 decreased significantly (P<0.05).Compared with T0 and group C, group D1,SpO2 in group D2 there was no statistical significance (P>0.05). Compared with group C, ICC score, PAED score and PHBQ case in group D1 and D2 decreased significantly (P <0.05). Compared with group D1, ICC score, PAED score and PHBQ case in group D2 there was no statistical significance (P>0.05).No obvious adverse reaction observed in 3 groups. Conclusion Dexmedetomidine preoperative intranasal drop 1 μg•kg-1 in children undergoing laparoscopic high ligation for incarcerated inguinal hernia could increase anesthesia induction compliance, decrease emergence delirium and post hospitalization behavior change, with no obvious adverse reaction. Dexmedetomidine intranasal drop 2 μg•kg-1 provide the same effect in anesthesia induction compliance, emergence delirium and post hospitalization behavior change, but MAP and HR decreased significantly.

Keywords

Dexmedetomidine, Intranasal, Pediatric, Emergence delirium, Laryngeal masks