Clinicopathological analysis of patients with primary hyperparathyroidism bone disease
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Zhixue Zheng, Jingtao Bi, Xuan Cai, Aimin Cui and Bai Nan
The clinical and pathological data of patients with primary hyperparathyroidism (PHPT) with or without bone disease were analyzed before and after, and the changes of the two were analyzed and compared. Methods The clinical data and follow-up results of 140 PHPT patients who were treated in the general surgery department of Beijing Jishuitan Hospital from January 2013 to December 2018 were retrospectively analyzed. Results Preoperative parathyroid hormone (PTH) increased in PHPT patients, and serum calcium increased in 134 (95.7%) patients. Patients with bone lesions had significantly higher PTH levels before surgery than those without bone lesions (p = 0.000), and postoperative PTH levels were significantly higher than those without bone lesions (p = 0.000). The level of 25- (OH) D3 was significantly lower in patients with bone lesions before operation than in those without bone lesions (p = 0.031), but there was no significant difference in postoperative 25- (OH) D3 (p> 0.05). Preoperative blood calcium levels were not statistically different between the two groups. Patients with bone lesions had significantly lower blood calcium levels at 1 day and 1 week after surgery than those without bone lesions. The level of ALP in patients with bone lesions was significantly higher than that in patients without bone lesions before surgery and 1 month after surgery, and there was no significant difference between the two at 1 year after surgery. Conclusion Surgery is an effective method for treating patients with PHPT. Compared with patients without bone disease, the levels of PTH, blood calcium, phosphorus, and ALP are significantly different before and after surgery. Therefore, in the clinical work, we have Patients with diseased PHPT should pay more attention to early detection and diagnosis, so as to reduce complications.
Primary hyperparathyroidism; Parathyroid hormone; Bone disease; Blood calcium