Preparation of Chitosan / Sodium Alginate Microspheres and Sustained Release in Propranolol Hydrochloride
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Yu Yang, Guangrong Zhao and Xiaojing Wang
Propranolol hydrochloride is a non-selective adrenergic drug that has been used as a drug for angina pectoris, antihypertensive and many other cardiovascular diseases. Objective: To determine the best process for chitosan / sodium alginate microspheres as a carrier of propranolol hydrochloride sustained release microspheres. Methods: SEM analysis, whether the surface of the microspheres is uniform and smooth, whether there are potholes, and the diameter of the microspheres. The release rate of propranolol hydrochloride adsorbed on the surface of drug-loaded microspheres was measured. Main measurement results: The release rate of propranolol hydrochloride adsorbed on the surface of drug-loaded microspheres reached 59.4% in 5 h. Results: The optimal process parameters were: emulsification time: 5 min, Span-80 dosage: 8 mg, drug loading: 30 mg. Conclusion: This process has prepared propranolol hydrochloride chitosan / sodium alginate microspheres. It is believed that chitosan / sodium alginate microspheres have a good sustained release effect as a carrier of propranolol hydrochloride.
Chinese picture classification number: TQ460.4 Document identification code: an Article ID:
Propranolol hydrochloride; Chitosan; Sodium alginate; Slow release