The Decoction of Tonifying Kidney and Activating Blood Circulation Directly Inhibits VEGF Pathway and Slows Down the Progression of Diabetic Retinopathy
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Jianbo Zhou, Xin Zheng, Lan Li, Xiaoyu He and Mei Zhang
To illustrate the effect of Bushen-Huoxue Decoction to the expression of advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR) rats and its effect on the process of DR. The blank group and STZ insulin resistance model group, positive group and administration group were established. The expression of VEGF and HIF-1 α and the concentration of AGEs in plasma were measured. The results of retina digestion showed that although there were different degrees of retinal vascular damage in the administration group, the damage was lighter than that in the model group, and the difference of E/P value was significant (P<0.01).The expression of VEGF and HIF-1 α in the administration group was between the blank group and the model group. The concentration of AGEs in the plasma of the positive group and the administration group was significantly lower, with a very significant difference (P<0.01). Bushen-Huoxue decoction has a marked therapeutic effect on DR, and its mechanism is closely related to the inhibition of VEGF expression.
Bushen-Huoxue Decoction; Vascular Endothelial Growth Factor; Diabetic Retinopathy; Chinese Traditional Medicine