Agt Gene Rs5049 Locus in the Pathogenesis of Hypertension
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Yao Guqiu, Jiang Qianfeng
Alcohol is a common addictive substance, which can lead to mental and physical dependence after long-term consumption. Large amounts of alcohol intake increase the risk of hypertension; some studies have shown that ethanol may activate renin-angiotensin- the aldosterone system raises hypertension; angiotensinogen (agt) is a rate-limiting substrate of the raas system, which is encoded by the agt gene, where the rs5049 site is the risk of essential hypertension (eh) genes; drinking may increase blood pressure by activating the raas system by altering the rs5049 locus of the agt gene.
Alcohol; Hypertension; Agt Gene; Raas System; Rs5049 Locus