Effects of Two Kinds of Neoadjuvant Chemotherapy on Lymphatic Density and Vascular Endothelial Growth Factor Expression in Cervical Cancer
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Liu Xiuhua, Guan Yinghui
Objective: to explore and analyze the effects of systemic intravenous chemotherapy and internal iliac artery embolization and perfusion chemotherapy on the microlymphatic vessel density and vascular endothelial growth factor expression in cervical cancer and its clinical efficacy. Methods: 110 cases of cervical cancer patients who were treated in our hospital from may 2018 to april 2019 were selected as the subjects. They were randomly divided into the reference group and the study group, with 55 cases in each group. Patients in the reference group were given systemic intravenous chemotherapy, while those in the study group were given intra-iliac artery embolization and perfusion chemotherapy. The effect of microlymphatic vessel density and vascular endothelial growth factor expression in the two groups were compared, as well as the actual treatment effect of the patients. Results: the total effective rate of the study group receiving internal iliac artery chemoembolization was 72.7%, and that of the reference group receiving systemic intravenous chemotherapy was 50.9%. The effective rate of the study group was significantly higher than that of the reference group, with a statistically significant difference (p<0.05). There was no significant difference in vegf-a, c and d between the two groups before treatment. After treatment, vegf-a and c in the reference group showed no significant changes, and vegf-d was significantly decreased (p<0.05). There was no significant change in vegf-a in the reference group, and vegf-c and d were significantly decreased. The vegf-c and d in the study group were (3.31±1.60) and (3.99±1.18), respectively, significantly lower than those in the reference group, with statistically significant differences (p<0.05). There was no significant difference in lmvd level between the two groups before treatment (p>, 0.05). After treatment, the lmed level of the study group was (5.20±2.11), significantly lower than that of the reference group (p<0.05). Conclusion: in the treatment of cervical cancer patients, the use of internal iliac artery chemoembolization can significantly reduce the density of lymphatic vessels and the expression of vascular endothelial growth factor, achieve better clinical efficacy, has a higher clinical promotion and application value.
Lymphatic Vessel Density; Vascular Endothelial Growth Factor; Systemic Intravenous Chemotherapy; Chemotherapeutic Embolization of the Internal Iliac Artery