Study on the preparation technology of Sanqi Shangyao gels for percutaneous absorption
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Shijun Liu, Lin Li, Zhishu Tang, Yu Zhang, Jing Sun, Zhongxing Song, Hongbo Xu, Chunli CuI, Hongbo Liu
Objective: To optimize the preparation technology and matrix ratio of Sanqi Shangyao gels. Methods: The effects of carbomer 940, sodium carboxymethyl cellulose and propylene glycol on the formation of gel matrix were investigated by orthogonal test, and the ratio of matrix and preparation process were determined. Results: The orthogonal test results showed that the matrix ratio was carbomer 940 1.5g, carboxymethyl cellulose sodium 2g, propylene glycol 10g, and the gel properties was superior when the proportion of other substrates was fixed. Conclusion: Preparation process and matrix ratio by orthogonal test is even and delicate, easy to be coated and stable.
Gels; Preparation process; Percutaneous absorption