Author(s)

Shijun Liu, Lin Li, Zhishu Tang, Yu Zhang, Jing Sun, Zhongxing Song, Hongbo Xu, Chunli CuI, Hongbo Liu

Corresponding Author

Shijun Liu

Abstract

Objective: To optimize the preparation technology and matrix ratio of Sanqi Shangyao gel plasters. Methods: The effects of sodium polyacrylate, gelatin and sodium carboxymethyl cellulose on the matrix formability of gel plasters were investigated by L9 (33) orthogonal test, and the optimum ratio of matrix was optimized by examining the formability, appearance of the dosage form, heat resistance, initial viscosity and human body sense. Results: Through the analysis of the orthogonal test and the results, Sanqi Shangyao gel plasters was superior with sodium polyacrylate 4g, sodium carboxymethyl cellulose 3g, gelatin 4g when the proportion of other matrix is fixed. Conclusion: Sanqi Shangyao gel plasters is stable, easy to adhere and no discomfort during strippingaccording to the technology and matrix ratio determined by orthogonal test.

Keywords

Percutaneous absorption; cataplasm; preparation process