Author(s)

Jian Wang, Yan Duan, Changpeng Xu, Li Gong, Yu Zhang, Limin Cen, Qiwen Sun

Corresponding Author

Jian Wang

Abstract

Belongs to the metabolic disease with the highest incidence rate. The middle-aged and elderly people are the main disease group. Osteoporosis may lead to an increased risk of fracture. Currently, the drugs for clinical treatment of OP mainly on drugs of inhibiting the bone resorption and promoting bone synthesis. With the gradual deepening of the research on the etiology and pathogenesis of OP, the bone targeting drugs such as cytokines, hormones and peptides have been widely used in clinical practice. All of them have certain curative effects, but there are limitations in the use of various drugs. It is important to find a bone targeting drug with strong bone-affinity and stable structure to improve the symptoms of bone loss in patients. Based on the above background, this paper summarizes the application of bone targeting drugs to OP, summarizes the mechanism and efficacy of various drugs, and concludes and prospects future application trends, hoping to provide more options for clinical drug use.

Keywords

Osteoporosis, Bone targeting drugs, Study progress