Author(s)

Su Hailin

Corresponding Author

Su Hailin

Abstract

Steroidal compounds have important physiological and pharmaceutical effects, and the market demand is huge. The steroidal compounds and their key steroids are prepared by microbial transformation, and are gradually applied to chemical synthesis methods with regional stereoselectivity, shortening synthesis steps, shortening production cycle, increasing yield and eco-friendliness. The catabolic mechanism needs to be further explored and determined. This paper summarizes the structure types and main sources of steroids, physiological functions, microbial transformation and catabolism mechanism, focusing on the key enzymes in the catabolism of steroids and their molecular mechanisms. Provide reference for the development of strains and the construction of engineering bacteria and the development of microbial transformation industrial production processes.

Keywords

Terpenoids, Microbial Transformation, Side Chain Degradation, Core Ring Degradation, Metabolic Mechanism