Imprinted Genes in Hematopoietic Stem Cells and Related Diseases
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Genomic imprinting is a phenomenon of epigenetic modification specific to alleles of paternal or maternal origin, leading to monoallelic expression. Imprinted genes are established in gametes, maintained after fertilization, and erased in early gametes, thus forming a cycle. Loss of imprinting is prone to many diseases, even cancer. In this paper, we will focus on the role of imprinted genes in hematopoietic stem cells, and the research of related diseases or treatments caused by imprinted genes in hematopoietic stem cells. In patients with short overall survival, the CpG site of Meg3-DMR is hypomethylated, resulting in increased expression of Meg3 and DLK1. In addition, FHES can imprint long-term hematopoietic stem cells and monocyte precursor populations, leading to the development of anti-inflammatory Ly6Clow monocytes in response to T-cell-mediated autoimmune diseases. In conclusion, hematopoietic stem cells (HSCs) are ideal target cells for gene therapy, because they are easy to be modified in vitro and can be expressed continuously in circulating peripheral blood cells.
Genomic imprinting, hematopoietic stem cells, deases, therapy