Author(s)

Wei Cai, Yinfeng Xu, Ziwei Zhao, Wenjuan Guo, Yanmei Tang

Corresponding Author

Yanmei Tang

Abstract

in the asymmetric synthesis of metal catalysis, chiral dioxazoline ligands have been widely used in various asymmetric catalytic processes, such as the formation of carbon-carbon bonds, due to their easy raw materials, easy synthesis and easy structure modification. Nitrogen heterocyclic propane reaction, oxidation reaction and hydrosilanization reaction all showed excellent chiral inductive properties. On the other hand, ferrocene is used as skeleton ligand, especially chiral ferrocene phosphine ligand, in addition to carbon-carbon double bond, hydrosilylation and reduction of dibasic compounds, Aldol reaction of aldehydes, Heck reaction. Cross coupling reactions and many other reactions also show High enantioselectivity. It is predicted that the chiral dioxazoline ligands with ferrocene as the skeleton will have better asymmetric inductive properties. In this paper, four chiral dioxazoline ferrocene ligands (Lip,Lph,Lbn,Lme,) have been synthesized to study their chiral induction properties in Cu (I) catalyzed asymmetric cyclopropane reaction and Mg (11) -catalyzed Diels Alder reaction.

Keywords

Ferrocene, Dioxazoline Chiral Ligands, Design, Synthesis, Inductive Properties, Catalysis